Visualization of Clot Lysis in a Rat Embolic Stroke Model
نویسندگان
چکیده
منابع مشابه
Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy.
BACKGROUND AND PURPOSE The purpose of this study was to develop a novel MRI method for imaging clot lysis in a rat embolic stroke model and to compare tissue plasminogen activator (tPA)-based clot lysis with and without recombinant Annexin-2 (rA2). METHODS In experiment 1 we used in vitro optimization of clot visualization using multiple MRI contrast agents in concentrations ranging from 5 to...
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See related article, page 1237–1243 Sudden occlusion of a brain artery by a blood clot represents the pivotal event in ischemic stroke. Consequently, most of the therapeutic effort during the acute stage of cerebral ischemia aims at resolving the thrombus to restore blood flow. Because the clot is the primary target of thrombolytic therapy, the definition of clot characteristics that are associ...
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Platelet facilitation of clot lysis was studied using the dilute clot lysis assay, a standardized assay for fibrinolysis shown to correlate with the development of postoperative deep vein thrombosis. Clots prepared from dilute platelet poor plasma showed prolonged clot lysis when compared with clots prepared in a similar fashion from dilute platelet rich plasma. Since in the presence of platele...
متن کاملProtective Effect of Delayed Ischemic Postconditioning on Embolic Stroke Complications in Female Rat
Background & Aims: Ischemic postconditioning, conducted by a series of brief occlusion and release of the bilateral common carotid arteries, has neuroprotective properties in permanent or transient models of middle cerebral artery (MCA) occlusion but its delayed neuroprotective effects in the embolic model of stroke, especially in female rat, have not yet been reported and were investigated ...
متن کاملMRI of Emboli Localization and Lysis in an Embolic Model of Rat Middle Cerebral Artery Occlusion
Introduction: The embolic model of rat middle cerebral artery occlusion is widely used for preclinical testing of neuroprotective drugs. While the time course of the perfusion and diffusion lesion have been described, little data has been collected to describe the time course of clot lysis during tissue plasminogen activator (tPA) administration in this model. To provide another level of charac...
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ژورنال
عنوان ژورنال: Stroke
سال: 2011
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.110.602102